Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington's disease
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چکیده
منابع مشابه
Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington's disease.
Growing evidence suggests that Huntington's disease (HD), a neurodegenerative movement disorder caused by the mutant huntingtin (htt) with an expanded polyglutamine (polyQ) repeat, is associated with the altered intracellular trafficking and synaptic function. GABA(A) receptors, the key determinant of the strength of synaptic inhibition, have been found to bind to the huntingtin associated prot...
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ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2012
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2012.02.015